• br Results br Discussion Cell

  2022-06-09

  

  Results Discussion Cell-contact-mediated spread of HIV-1 has been estimated to be at least an order of magnitude more efficient compared to passive dissemination of particles through the extracellular milieu. Thus, this form of viral transmission can have significant effects on the pathogenesi

• The effect of exercise on plasma ghrelin has previously

  2022-06-09

  

  The effect of exercise on plasma ghrelin has previously been investigated mostly in humans using exercise regimens such as treadmill running, cycling, and rowing, and also in a few rodent studies and in some other animal models. While many of these clinical studies and some preclinical studies demon

• uPAR another newly discovered ligand has implicated FPRL as

  2022-06-09

  

  uPAR, another newly discovered ligand, has implicated FPRL1 as a potential link between the fibrinolytic cascade and inflammation. uPA is a serine protease best known for its ability to regulate fibrinolysis and for its importance in tissue remodeling and tumor invasion [49]. However, uPA also induc

• To further investigate if GPR was the functional target of

  2022-06-09

  

  To further investigate if GPR40 was the functional target of these phenylpropiolic CCT007093 analogs, GW-1100, a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells with an IC50 value equal to 1 μM, was used to inhibit agonist-induced intracellular calcium flux [15]. HEK293-GPR40 

• br Declaration of interest br Acknowledgments br This

  2022-06-09

  

  Declaration of interest Acknowledgments This work was supported by grants from the Polish National Science Centre (PRELUDIUM grant no. 2013/11/N/NZ5/00270) and the European Commission FP7 Project Beta-JUDO (grant number 279 153), European Union EIT Health project DeTecT2D, Swedish Diabetes A

• br Introduction The term autophagy was coined by

  2022-06-09

  

  Introduction The term “autophagy” was coined by Christian de Duve in 1963 to describe the process of removing and degrading intracellular components such as unused proteins and damaged organelles through lysosomes [1,2]. Autophagy has been divided into three main types, namely, macroautophagy, mi

• Introduction Ventilator induced lung injury

  2022-06-09

  

  Introduction Ventilator-induced lung injury(VILI) is the most common complication in the mechanical ventilation in clinic. Repetitive opening and closing of FH1 australia at high pressures during artificial ventilation would generate shear stress and then lead to the damage of cell junction and dy

• Data of initial analogs have been shown in wherein SAR

  2022-06-09

  

  Data of initial analogs (±)-– have been shown in wherein SAR was observed for the intended change of the right-hand side pyridin-3-yl ring of to various other -containing heteroaryl ring (Ar) disposing the ring- at different directions. Based on consistent human and rat FAAH potency as well as intri

• Amrubicin br Materials and methods br Results br

  2022-06-09

  

  Materials and methods Results Discussion This was the first large study to quantify both total HIV DNA and integrated HIV DNA, which is the main persistent form of HIV [25,26], in samples collected during PHI, chronic infection, and at various time points until the AIDS stage, which was mad

• Several bacterial functional pathways were observed after DO

  2022-06-08

  

  Several bacterial functional pathways were observed after DON administration, of which signal transduction, metabolism and genetic information processing displayed the highest levels of enrichment. Importantly, these three pathways were reported to be closely associated with DON's toxicity. Many evi

• Over the last years numerous studies gave

  2022-06-08

  

  Over the last 15 years, numerous studies gave insights into sGC activation and binding of activators: Photoaffinity labelling studies with cinaciguat suggested the N-terminus of the β1 subunit as target region for this new drug [17]. Schmidt et al. identified the amino acids tyrosine 135, serine 137

• Spatial localization of zGC and

  2022-06-08

  

  Spatial localization of zGC and zGCAP transcripts by in situ hybridization was detected in the ONL. No transcripts were detected in the outermost periphery of the photoreceptor cell layer adjacent to the marginal zone. This region is described as the area of cone genesis and maturation [29], which f

• Chronic exposure of cells to cytotoxic drugs can result in

  2022-06-08

  

  Chronic exposure of cells to cytotoxic drugs can result in the selection of multiple phenotypic and genetic changes. Thus, the use of MCF7/VP cells, which were selected for resistance to VP-16, was potentially problematic. However, a thorough characterization of MCF7/VP cells demonstrated that they

• Introduction Epigenetic alterations play an

  2022-06-08

  

  Introduction Epigenetic alterations play an important role in carcinogenesis. Aberrant promoter CpG island hypermethylation causes transcriptional gene silencing [1], and has been documented for a number of genes in prostate cancer (PCA) [2]. Histone modifications are also important regulators of t

• One important aspect about GSK inhibitors is their

  2022-06-08

  

  One important aspect about GSK-3 inhibitors is their effect on pluripotency of orexins [4]. Many GSK-3 inhibitors are ATP-competitive and suppress both GSK-3alpha and GSK-3beta [476]. BIO was shown to suppress GSK-3 activity and promote Wnt/beta-catenin signaling. This combination of events preserv

15299 records 394/1020 page Previous Next First page 上5页 391392393394395 下5页 Last page