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Our results on the acute effects
2021-08-10
Our results on the acute effects of THC on resting state Gentamycin Sulfate function are in line with previous neuroimaging findings. Increased perfusion after THC administration in insular and prefrontal regions has previously been reported in smaller samples (Mathew et al., 1997, Mathew et al., 2
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br Most reported binding data are obtained by
2021-08-10
Most reported binding data are obtained by performing heterologous competition binding experiments and expressing the results as relative binding affinity (RBA). The constructed binding curves should theoretically be sigmoidal in shape with a Hill slope value of one, for a single ligand binding t
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Williamson et al interrogated the fusion gene status
2021-08-10
Williamson et al. [30] interrogated the fusion gene status of 210 appropriately reviewed and annotated RMS specimens divided into three groups: ERMS (n=77); fusion gene-positive ARMS (n=94); and fusion gene-negative ARMS (n=39), the latter comprising a group of tumor samples that appeared histologic
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An important focus of the
2021-08-10
An important focus of the present study has been the interaction of HUVECs with extracellular matrix in the regulation of angiogenesis. Matrigel is a gelatinous protein extract secreted by Engelbreth–Holm–Swarm mouse sarcoma cells, and is considered to be a good model of the extracellular matrix (Kl
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br Conclusions Nanoparticles can be used to modulate
2021-08-10
Conclusions Nanoparticles can be used to modulate the catalytic activity of various industrially and clinically useful enzymes, as well as pH, temperature and storage stabilities, which will enable the process to occur more efficiently and less costly. The interaction between an enzyme and nanopa
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In the previous study glutamyl endopeptidase of
2021-08-10
In the previous study glutamyl endopeptidase of B. intermedius has been reported to be distributed in the inhibitor chemistry mg of B. intermedius as follows: 90% of synthesized enzyme has been detected in the culture liquid, 9.3% of glutamyl endopeptidase—in the fraction of membrane proteins [20].
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ddhGTP of br Discussion The regulation of intracellular
2021-08-09
Discussion The regulation of intracellular cholesterol levels is a biological process of vital importance for cellular function and integrity, and involves robust transcriptional and post-transcriptional mechanisms that are sensitive to metabolic feedback control. Amongst post-transcriptional mec
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br Acknowledgements This work was supported by National
2021-08-09
Acknowledgements This work was supported by National Natural Science Foundation of China (No. 81400241). Introduction Fluoride, as a member of the halogen group of elements, naturally existed in water, soil, animals, and plants around the world (Singh et al., 2018), and it is present in trace
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Most of the amino acid residues
2021-08-09
Most of the amino GDC-0349 residues contacting the substrate are within the nucleotide-recognition lid (mauve or magenta in Fig. 4A). Two particularly important residues, W69 and Y76, are conserved in eubacteria and in some but not all of eight human AlkB homologs [52], [76] (Fig. 4B). The tryptoph
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The overall poor outcomes in ESCC
2021-08-09
The overall poor outcomes in ESCC are thought because of a combination of late diagnosis, aggressiveness of the disease, and a lack of effective treatment strategies for systemic disease. Several molecular pathways, such as epidermal growth factor receptor, vascular endothelial growth factor, and p5
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br Materials and methods br Results br
2021-08-09
Materials and methods Results Discussion In this study, we developed a new CysLT1 and CysLT2 receptors-mediated prostaglandin endoperoxide synthase guinea pig model for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. Unlike human CysLT2 receptors, which are equally stimula
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We propose two hypotheses to interpret
2021-08-09
We propose two hypotheses to interpret our findings. The first, ELR (+) CXC chemokines stimulate both CXCR-1 and CXCR-2 chemokine receptor while activating neutrophils; however CXCR-1 chemokine receptor seems to play more active role in the process of neutrophil migration as shown in previous studie
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br Materials and methods br Results br
2021-08-09
Materials and methods Results Discussion Consistent with previous reports (Barr et al., 2010, Vuong et al., 2010), the current study demonstrates that rats treated with amphetamine exhibit heightened anxiety states during withdrawal. Furthermore, icv. infusion of a CRF2 receptor antagonist
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Two major mechanisms including apoptosis and oxidative stres
2021-08-09
Two major mechanisms including apoptosis and oxidative stress have been suggested for MTX-induced cytotoxicity (Hafez et al., 2015; Neuman et al., 1999; El-Sheikh et al., 2015). It has been reported that MTX promotes cell death via apoptosis in both cancerous and non-transformed cells (Mazur et al.,
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br Results br Discussion br
2021-08-09
Results Discussion Experimental Procedures Author Contributions Acknowledgments Introduction Excitatory synaptic transmission within the brain is largely mediated by ionotropic glutamate receptors. At glutamatergic synapses, α-amino-3-hydroxy-5-methylisoxazole-4-proprionic aromatas
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