• We found all cases to show at least

  2021-05-26

  

  We found all cases to show at least some IGF-1R expression by immunohistochemistry. This is consistent with its ubiquity at the mRNA or protein level in ES/PNET cell lines or clinical samples as shown by others.12, 14 Evidence that IGF-1R expression is required for EWS-FLI1 transformation of mouse f

• Studies have recently raised concerns about the potential ro

  2021-05-26

  

  Studies have recently raised concerns about the potential role of parabens in breast cancer, as these chemicals are commonly detectable in human breast cancer tissues. An analysis of 160 breast tissue samples collected from 40 mastectomies for primary breast cancer in England showed that at least on

• In human neuroblastoma SH SY Y cells and

  2021-05-26

  

  In human neuroblastoma SH-SY5Y AR-M 1896 and in lymphoma Jurkat cells, Yamanaka et al. [56] showed that exogenously added 24(S)-hydroxycholesterol could be efficiently esterified by ACAT1. These results suggest that both ACAT1 and ACAT2 can control the oxysterol levels by directly esterifying them,

• A great deal of research has focused

  2021-05-25

  

  A great deal of research has focused on candidate medications to modulate dopaminergic mechanisms through which psychomotor stimulants produce addictive effects, i.e., drugs that expressly target the DA transporter, D1-like receptor, or D2-like receptors., , However, effective dopaminergic-based ph

• cGAS has a central role in STING

  2021-05-25

  

  cGAS has a central role in STING activation after DNA sensing, but it is unknown if most of the DNA sensors act independently or in cooperation with the cGAS-cGAMP pathway. This was addressed for IFI16 (Almine et al., 2017, Jønsson et al., 2017) and PQBP1 (Yoh et al., 2015) but remains to be tested

• DAPK is a kD Ca

  2021-05-25

  

  DAPK is a 160-kD Ca2+/calmodulin (CaM)-regulated Ser/Thr kinase that mediates cell death. The activated forms of DAPK and DRP-1 are capable of inducing two distinct cytoplasmic events characteristic of programmed cell death, including membrane blebbing and the formation of autophagic vesicles (Inbal

• Functionally all members of the

  2021-05-25

  

  Functionally, all members of the IL-12 family have been annotated along major inflammatory signaling axes but their roles have often weighed on opposing sides of the immunological balance. For instance, IL-12 and IL-23 are classified as pro-inflammatory cytokines [10] as opposed to the rather protec

• Dopamine activity in the PFC

  2021-05-25

  

  Dopamine activity in the PFC and striatum may be antagonistic, meaning that lower levels of dopamine in the striatum tend to correspond to higher levels of dopamine in the PFC and vice versa (Cools and D'Esposito, 2011; Tunbridge et al., 2006). Human PET studies have reported that dopaminergic PFC f

• The importance of AAE in enhancing the

  2021-05-24

  

  The importance of AAE3 in enhancing the survival of plants and yeast when confronted with certain environmental stresses has been documented in recent reports. In response to biotic stress such as oxalate-secreting micro-organisms, AAE3 was found to reduce the inhibitory growth effects of the secret

• Lavallee et al reported that PREG could be esterified

  2021-05-24

  

  Lavallee et al. [30] reported that PREG could be esterified by lecithin:cholesterol acyltransferase (LCAT). LCAT uses cholesterol and phosphatidyl choline present in the newly formed high-density lipoprotein (HDL) as substrates and convert them into cholesteryl esters and lysophosphatidyl choline. T

• In principle in vitro techniques for assessing enzyme

  2021-05-24

  

  In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized prostanoid receptors lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with recomb

• br Experimental Procedures br Author Contributions br Acknow

  2021-05-24

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Oxysterols came to prominence in the late 1970's with the oxysterol hypothesis which proposed that the suppressive effect of cholesterol on its own synthesis is mediated through oxysterols not by cholesterol itself

• Although many GPCR heteromers have been identified

  2021-05-24

  

  Although many GPCR heteromers have been identified using heterologous cell lines, only very few fit all three criteria. This is mainly due to the difficulties to study these structures in native tissues because of the lack of sensitive and selective tools, not only capable of detecting in vivo evide

• During these processes meiotic recombination plays

  2021-05-24

  

  During these processes, meiotic recombination plays a critical role by physically associating homologs and ensures accurate chromosome segregation. In addition, meiotic recombination redistributes genetic material between homologs, resulting in haplotype diversity among progeny, impacting ecological

• br Cytokines and NK cells br Combined effects

  2021-05-24

  

  Cytokines and NK cells Combined effects of cytokines and other stimuli on NK cell function Cytokine-stimulated NK ep4 receptor have enhanced capacity to kill tumor cells. However, usually, individual cytokines do not seem to be sufficient for full activation, proliferation, survival and effec

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