• DNA replication checkpoint kinases in both yeast

  2020-12-31

  

  DNA replication checkpoint kinases in both yeast and human Sitafloxacin Hydrate upregulate dNTP levels under replication stress to mediate their essential function at replication forks (Yeeles et al., 2013). It is possible that upregulation of dNTP levels under replication stress helps fork restart

• br Roles of TLS polymerases outside DNA damage tolerance br

  2020-12-31

  

  Roles of TLS polymerases outside DNA damage tolerance Preparing the ground for more DNA damage: adaptive responses through gene induction Conclusions and perspectives Although known for many decades, the relevance of TLS in genome stability is normally considered secondary to mechanisms tha

• The folate pathway plays an essential role in cell

  2020-12-31

  

  The folate pathway plays an essential role in cell survival by generating 5, 10-methylene tetrahydrofolate as a one-carbon donor for the synthesis of deoxythymidine monophosphate (dTMP), purines, methionine and histidine. Disruption of this pathway leads to the critical deficiency of these key molec

• In order to gain further insights into the role

  2020-12-31

  

  In order to gain further insights into the role of peptidases in B. xylophilus, four cysteine proteases highly secreted by B. xylophilus (Cardoso et al., 2016) were selected four further characterisation. Materials and methods Results and discussion Structural prediction and analysis The i

• In the brain E can modulate the

  2020-12-31

  

  In the brain, E2 can modulate the mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) pathway, which is involved in the formation of different memory types (Atkins et al., 1998, Blum et al., 1999, Schafe et al., 2000). When the MAPK/ERK signaling pathway is activated,

• br Experimental Procedures br Author Contributions br Acknow

  2020-12-31

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Estrogen-related receptors (ERRα, ERRβ, and ERRγ) are orphan nuclear receptors whose physiological ligands have not yet been identified. Although ERRs are closely related to estrogen receptors (ERs) they do not res

• The activity of cysteine endopeptidases involved in the germ

  2020-12-30

  

  The activity of cysteine endopeptidases involved in the germination of caryopses is generally regulated at two levels: the hormonal induction of synthesis by gibberellins (Drzymała et al., 2008) and a putative regulation of activity by phytocystatines (Kiyosaki et al., 2007, Martinez et al., 2009),

• Recent results from our group found

  2020-12-30

  

  Recent results from our group found that SPMs, not only play a part in terminating inflammation, but also have a physiological role in conjunctival goblet JQ1 to maintain ocular surface health in the absence of disease. Amongst the SPMs that are effective in the conjunctiva are resolvin D1 (RvD1), a

• br Experimental Procedures br Author

  2020-12-30

  

  Experimental Procedures Author Contributions M.B., with input and help from T.T.H., conceived the project, designed and performed the experiments, analyzed the data, and wrote the manuscript. B.B.B. and F.D.M. synthesized the wild-type and (nonhydrolyzable, NH) Ub tetramers and contributed Fig

• In attempts to further purify His Artemis numerous matrices

  2020-12-30

  

  In attempts to further purify [His]6-Artemis, numerous matrices were assessed including anion and cation exchange, and Fmoc-Gly-OPfp interaction chromatography. The results from these matrices were universally poor (data not shown). Fractionation via adsorption chromatography on a hydroxyapatite (H

• Sequence alignment of cfALDH with the

  2020-12-30

  

  Sequence alignment of cfALDH with the human ALDH1 indicates that the cyanobacterial protein contains the same GQCC motif as the human ALDH1 and ALDH2 proteins [24] (Fig. 1d, highlighted in red, and Supplementary Fig. 2). This motif is present in ALDH1/2 orthologues and these residues reside at the b

• H 89 australia br Author contribution br Acknowledgements QN

  2020-12-30

  

  Author contribution Acknowledgements QNRF grant number NPRP6-065-3-012, Qatar National Research Fund, Doha Qatar for funding this work with grant number NPRP No.: NPRP6-065-3-012. Introduction Preeclampsia (PE) affects 3–5 % of pregnancies worldwide and is one of the leading causes of mate

• Patients and methods This study was performed

  2020-12-30

  

  Patients and methods This study was performed at 3 academic centers (Chung-Ang University YongSan Hospital, Soonchunhyang University Hospital, and Chung-Ang University Hospital) in Seoul, Korea, from November 2008 to November 2010. The study protocol was approved by the institutional review boards

• LDN-212854 Another potential source of variable affinities i

  2020-12-30

  

  Another potential source of variable affinities is inherent in the method of RBA determination. While several reports simply use relative IC50 values as RBAs [11], [12], [13], [14], [15], these are only an approximate measure of relative affinity since IC50 varies due to experimental and biological

• We recently employed a functional drug

  2020-12-30

  

  We recently employed a functional drug screening approach to identify mithramycin as an inhibitor of EWS–FLI1. In our study, we employed a stepwise approach involving a luciferase primary screen and a novel multiplex PCR screen to evaluate over 50,000 compounds to identify mithramycin as an inhibito

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