• Canagliflozin Hemihydrate: SGLT2 Inhibition Beyond Glucos...

  2025-09-26

  Explore Canagliflozin hemihydrate as a small molecule SGLT2 inhibitor for advanced glucose metabolism research. This article uniquely examines its selectivity, mechanistic boundaries, and translational research potential, offering deeper insights than conventional reviews.

• NHS-Biotin: Unveiling Molecular Precision in Intracellula...

  2025-09-25

  Discover the advanced biochemical mechanisms and novel research frontiers enabled by NHS-Biotin, an amine-reactive biotinylation reagent. This in-depth analysis explores unique intracellular and multimeric protein labeling strategies, setting a new benchmark beyond conventional protocols.

• Panobinostat (LBH589): Unveiling HDACi-Induce

  2025-09-24

  Explore how Panobinostat (LBH589), a broad-spectrum HDAC inhibitor, uniquely induces apoptosis in cancer cells through advanced epigenetic and RNA Pol II-dependent mechanisms. This in-depth analysis reveals new insights for epigenetic regulation research and cancer therapy beyond current literature.

• Sulfo-NHS-SS-Biotin Kit: Advanced Strategies for Reversib...

  2025-09-23

  Explore advanced applications of the Sulfo-NHS-SS-Biotin Kit, a water-soluble amine-reactive biotinylation reagent, in dissecting cell surface proteomes and dynamic protein interactions. This article provides rigorous insights into reversible biotin labeling with disulfide cleavage, emphasizing its impact on high-resolution cell surface protein studies.

• BGJ398 (NVP-BGJ398): Distinct Applications in FGFR Signal...

  2025-09-22

  Explore the role of BGJ398 (NVP-BGJ398), a selective FGFR inhibitor, in both oncology and developmental biology research. This article highlights its utility in dissecting FGFR signaling pathways in cancer and emerging insights from developmental models.

• N1-Methylpseudouridine: Unveiling Mechanisms in mRNA Tran...

  2025-09-19

  Explore the multifaceted role of N1-Methylpseudouridine in mRNA translation enhancement, with a focus on its impact on reduced immunogenicity in mRNA and translational regulation. This article provides new insights into the mechanistic basis and experimental application of this modified nucleoside for protein expression in disease models.

• Genotyping Kit for Target Alleles: Accelerating Molecular...

  2025-09-18

  Explore how the Genotyping Kit for target alleles of insects, tissues, fishes and cells enables rapid, contamination-free genomic DNA preparation for PCR, advancing molecular biology genotyping research in diverse non-mammalian systems.

• The original Aurora kinase was identified during

  2025-04-22

  

  The original Aurora kinase was identified during a phenotypic screen for defects in mitotic spindles in Drosophila mutants. Aurora mutants were so named because of the morphological defects at the mitotic spindle resembling the Aurora borealis, or the Northern light [4]. The structure of the Auroras

• ATM is generally regarded to be the

  2025-04-17

  

  ATM is generally regarded to be the principal mediator of the G1 3X (DYKDDDDK) Peptide checkpoint, whereas the induction of the intra-S-phase and G2/M checkpoints are usually primarily related to ATR function. However, several studies have demonstrated that, depending on the cellular context and ty

• Why do glutamate and glycine bind

  2025-04-16

  

  Why do glutamate and glycine bind to the HotStart™ 2X Green qPCR Master Mix in such different ways? Given the overall structural similarity between the GluN2A and GluN1 LBDs, one might conclude that the LBDs also bind ligands via similar processes. NMDA receptors with engineered disulfide linkages t

• Recent progress has been made in

  2025-04-16

  

  Recent progress has been made in translating animal findings on memory performance and amnestic effects – that are largely determined by tonically active receptors in which α5 contributes to the benzodiazepine binding site. Based on the observation that deletion of this subunit led to improved spati

• Receptors containing an x y subunit interface

  2025-04-16

  

  Receptors containing an αx/γy subunit interface, where x=1, 2, 3, 5 and y=1–3, form a high-affinity binding site for benzodiazepines (Figure 1A), for the later developed Z-drugs of different chemotypes, and for a large number of chemically distinct research compounds 17, 18 (Box 1 for examples). For

• Songbirds are outstanding models in the study of

  2025-04-15

  

  Songbirds are outstanding models in the study of vocal communication (Maney and Pinaud, 2011). Following the pioneering studies of William H. Thorpe and Peter Marler on the development of song in chaffinches (Fringilla coelebs) and white-crowned sparrows (Zonotrichia leucophrys) (Marler, 2004; Thorp

• Y-27632 dihydrochloride br Acknowledgements This work was su

  2025-04-14

  

  Acknowledgements This work was supported by the Victorian Government Operational Infrastructure Support Program. KAB is supported by the Mavis Robertson Fellowship from the National Breast Cancer Foundation (NBCF; ECF-16-004), by an NBCF Novel Concept Award (NC-14-011), and by NHMRC project grant

• br Materials and methods br Results br Discussion Fluoride

  2025-04-11

  

  Materials and methods Results Discussion Fluoride can readily penetrate cellular membranes and seriously damage the structure and physiological function of cells (Zhou et al., 2015). Several studies have shown that excessive fluoride can decrease the viability of cells and that the growth o

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